U-500 is a different kind of insulin compared to standard regular insulin (U-100), as it covers both long-acting and mealtime insulin needs, which could mean fewer daily injections. The risk of hypoglycemia associated with HUMULIN R U-500 use may be increased with antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Patients taking HUMULIN R U-500 may experience injection site reactions, including injection site hematoma, pain, hemorrhage, erythema, nodules, swelling, discoloration, pruritus, warmth, and injection site mass. Skin thickening or pits at the injection site (lipodystrophy). Do not use if it has been frozen. Use Humulin R U-500 exactly as your healthcare provider tells you to. Carefully replace the Outer Needle Shield. Read Humulin®R U-500 KwikPen® Instructions for Use. Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA. Humulin R U-500 contains 5 times as much insulin (500 units/mL) in 1 mL as standard insulin (100 units/mL). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction: low potassium in your blood (hypokalemia). In a euglycemic clamp study of 24 healthy obese subjects (BMI=30-39 kg/m2), single doses of HUMULIN R U-500 at 50 units (0.4-0.6 unit/kg) and 100 units (0.8-1.3 unit/kg) resulted in a mean time of onset of action of less than 15 minutes at both doses and a mean duration of action of 21 hours (range 13-24 hours). Do not use Humulin R U-500 in an insulin pump or inject it into your vein or muscle. Humulin R U-500 is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day. Put your used Needles in a FDA-cleared sharps disposal container right away after use. Humulin U-500 Conversion Chart Mar 2011 This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Push the Dose Knob in until it stops, and “. Frequent glucose monitoring and insulin dose reduction may be required in patients with hepatic impairment. Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe. Confirm that the patient has understood these instructions and can correctly draw the prescribed dose of HUMULIN R U-500 with their syringe. The estimated background risk of miscarriage for the indicated population is unknown. DO NOT transfer HUMULIN R U-500 from the HUMULIN R U-500 KwikPen into any syringe for administration as overdose and severe hypoglycemia can occur, The HUMULIN R U-500 KwikPen is for single patient use only. are pregnant, planning to become pregnant. Humulin R U-500 may pass into your breast milk. Extreme caution must be observed in the measurement of dosage because inadvertent overdose may result in serious adverse reaction or life-threatening hypoglycemia. HUMULIN R has the empirical formula C257H383N65O77S6 with a molecular weight of 5808. Inject Humulin R U-500 under your skin. Do not select your dose by counting clicks. Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use). Allergic reactions, such as redness and swelling at the site where you inject. What is Humulin R U-500 (Concentrated)?Overview|Dosage|Warnings|Side Effects. Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500. Always check the number in the Dose Window to make sure you have dialed the correct dose. Use only a U-500 insulin syringe with HUMULIN R U-500 to avoid administration errors. *, 1. Individualize and titrate the dosage of HUMULIN R U-500 based on the patient's metabolic needs, blood glucose monitoring results, and glycemic control goal. Read the information that comes with your prescription each time your prescription is filled. Humulin R U‑500 contains 5 times as much insulin in the same volume (500 units/mL) as standard insulin (100 units/mL). Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Always use a U-500 syringe to inject Humulin R U-500 insulin. Talk to your doctor about low blood sugar symptoms and treatment. It is also used along with glucose to treat high blood potassium levels. What is Humulin R U-500 (Concentrated)? Check for the green U-500 symbol and green Needle Shield. Figure 1 should be considered a representative example since the time course of action of insulin may vary in different individuals or within the same individual. Your doctor can check if the medicine has ingredients that may cause a reaction. In-use vials must be used within 31 days or be discarded, even if they still contain Humulin R U-500. The rate of insulin absorption and consequently the onset of activity is known to be affected by the site of injection, exercise, and other variables [see Warnings and Precautions (5.3)]. It is not known if Humulin R U-500 is safe and effective in children. Please confirm below. Do not dial your dose by counting the clicks. Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN R U-500 is co-administered with these drugs. The link you clicked on will take you to a site maintained by a third party, which is solely responsible for its content. Disease-associated maternal and/or embryo/fetal risk. If you do not have a U-500 syringe, you should contact your health care provider or pharmacist. Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function, changes in medications or during acute illness to minimize the risk of hypoglycemia or hyperglycemia. Throw away the opened vial after 40 days, even if there is still insulin left in the vial. Important Facts About Humulin® (HUE-mu-lin) R U-500. Take it exactly the way your doctor tells you. It is used to treat type 1 diabetes, type 2 diabetes, gestational diabetes, and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. As in adults, the dosage of HUMULIN R U-500 in pediatric patients must be individualized based on metabolic needs and results of frequent monitoring of blood glucose. If your dose is more than the number of units left in the Pen, you may either: It is normal to see a small amount of insulin left in the Pen that you cannot inject. The majority of errors occurred due to errors in dispensing, prescribing or administration. What should I tell my healthcare provider before using Humulin R U-500? Elimination — Mean apparent half-life after subcutaneous administration of single doses of 50 units and 100 units to healthy obese subjects (N≥21) was approximately 4.5 hours (range=1.9-10 hours) for HUMULIN R U-500. Humulin R U-500 may cause serious side effects that can lead to death, including: severe allergic reaction (whole body reaction). Store unused Pens in the refrigerator at 36°F to 46°F (2°C to 8°C). are breast-feeding or plan to breastfeed. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended. Symptoms may be different for each person. Humulin R U-500 is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day. Humulin® is a trademark of Eli Lilly and Company. Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. BD™ is a trademark of Becton, Dickinson and Company. Instructions for Use This will help you avoid infection. Inject Humulin R U-500 under the skin (subcutaneously) of your upper legs (thighs), upper arms, buttocks or stomach area (abdomen). Written by Cerner Multum. U-500 is 5 times more concentrated than standard U-100 insulin. Excess insulin administration may cause hypoglycemia and hypokalemia. Do not take this medicine if you have low blood sugar. When insulin is concentrated, it takes less liquid per dose than standard U-100 insulin to help reduce your blood sugar levels. take other medicines, especially ones called TZDs (thiazolidinediones). Severe, life-threatening, generalized allergy, including anaphylaxis, generalized skin reactions, rash, angioedema, bronchospasm, hypotension, and shock may occur with any insulin, including HUMULIN R U-500 and may be life threatening. Do not freeze. DO NOT dilute or mix HUMULIN R U-500 with any other insulin products or solutions. Pull off the Inner Needle Shield and throw it away. This could cause severe overdose and may lead to death. HUMULIN R U-500 contains 500 units of insulin in each milliliter. U-500 syringes allow 5 to 250 units per injection. If you cannot remove the Pen Cap, gently twist the cap back and forth, and then pull the cap straight off. Lilly USA, LLC does not control, influence, or endorse this site, and the opinions, claims, or comments expressed on this site should not be attributed to Lilly USA, LLC. This strength contains 500 units of insulin per 1 mL of solution. Use HUMULIN R U-500 KwikPen with caution in patients with visual impairment that may rely on audible clicks to dial their dose. Each turn (click) of the Dose Knob dials 5 units of insulin. Instruct patients to inject HUMULIN R U-500 subcutaneously usually two or three times daily approximately 30 minutes before meals. Always reorder. Changing insulin may lead to low or high blood sugar. It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins. Do not use if it has been frozen. This can lead to severe breathing problems, irregular heartbeat, and death. The glucose lowering effect of HUMULIN R U-500 may be increased or decreased when co-administered with alcohol, beta-blockers, clonidine, and lithium salts. Continue holding your Pen with Needle pointing up. SEVERE OVERDOSE CAN RESULT. Make sure you have a new U-500 Syringe. Power 2018-2020 U.S. Pharmacy Studies of customers’ satisfaction with their pharmacy. Patients using HUMULIN R U-500 vials should never share needles or U-500 insulin syringes with another person. DO NOT perform dose conversion when using a U-500 insulin syringe. It is a short-acting insulin that starts working about 30 minutes after it is injected. Each milliliter of HUMULIN R U-500 also contains glycerin 16 mg, metacresol 2.5 mg, zinc oxide to supplement the endogenous zinc to obtain a total zinc content of 0.017 mg/100 units, and Water for Injection. severe hypoglycemia needing hospitalization or emergency room care, and be sure to tell the hospital staff the units of Humulin R U-500 that your healthcare provider has prescribed for you. Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN R U-500 is co-administered with these drugs. Common Brand(s): Humulin R Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Do not change the insulin you use without talking to your doctor. This device is recommended for use with Becton, Dickinson and Company's insulin pen needles. Available data from published literature suggests that exogenous human insulin products, including HUMULIN R, are transferred into human milk. If you have any questions about Humulin R U-500 insulin or U-500 syringes, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979). Available data from published studies over decades have not established an association with human insulin use during pregnancy and major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data). Copyright © 1996, 2019, Eli Lilly and Company. It is not known if Humulin R U-500 is safe and effective when given by continuous subcutaneous infusion. ©Lilly USA, LLC 2020. It is not known if Humulin R U-500 is safe and effective when used with other insulins, when used in an insulin pump, or in children. HUMULIN R U-500 contains 500 units of insulin in each milliliter. Humulin R U-500 is a concentrated insulin. HUMULIN R U-500 is a sterile, aqueous, and colorless solution. The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. •If you use another kind of syringe, you may get a dangerous overdose. The Dose Indicator should line up with your dose. This could cause severe overdose and may lead to death. Most patients will require 2 to 3 daily injections of U-500. HUMULIN R U-500 contains 500 units of insulin in each milliliter. Be sure to check that you received Humulin R U-500 and that your medication has not expired. Humulin N, Humalog, metformin, Trulicity, Lantus, Victoza, Tresiba, Levemir, Novolog, Basaglar. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Make sure it says Humulin R U-500. Only use Humulin R U-500 if the solution appears clear and colorless. Instruct patients to always inspect insulin vials to confirm that the correct insulin is dispensed including the correct insulin brand and concentration. Change (rotate) where you inject your insulin with each dose. Replace the Pen Cap by lining up the Cap Clip with the Dose Indicator and pushing straight on. It is also known as insulin human injection (500 units/mL). 2015;21(7):782-793. Most patients will require 2 or 3 daily injections of U-500.1. Low potassium in your blood (hypokalemia). U-500 syringe – for single injection only. The safety and efficacy of HUMULIN R U-500 delivered by continuous subcutaneous infusion has not been determined. Then your card will be ready to be shared with your specialty pharmacy. Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. Sodium hydroxide and hydrochloric acid may be added during manufacture to adjust the pH. Generic Name: insulin human Dosage Form: injection, solution Indications and Usage for Humulin R U-500 HUMULIN R U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than 200 units of insulin per day. Keep away from heat and light. A place where we can all get together and talk and share information Wipe your skin with an alcohol swab, and let your skin dry before you inject your dose. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. Inject your insulin exactly as your healthcare provider has shown you. HUMULIN® R U-500 KwikPen®, insulin human injection U-500 (500 units/mL, 3 mL single-patient-use pen). In patients who are hypersensitive to HUMULIN R U-500 or any of its excipients. Rotate insulin injections sites within the same region to reduce the risk of lipodystrophy [see Dosage and Administration (2.1)]. Ask your pharmacist for an accurate price at time of sale. you can give yourself a 5 times overdose. Throw away the Pen you are using after 28 days, even if it still has insulin left in it. are having an episode of low blood sugar (hypoglycemia). U-500 is specifically for people like you – people whose A1C levels are above their target even though they’ve been taking more than 200 units of insulin each day. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for HUMULIN R and any potential adverse effects on the breastfed child from HUMULIN R or from the underlying maternal condition. ǂThe purpose of the study was to compare the efficacy and safety of 2 dosing treatments (2 or 3 injections per day) of U-500 in adults with type 2 diabetes who were uncontrolled with high doses of standard U-100 insulin. Make any changes to a patient's insulin regimen under close medical supervision with increased frequency of blood glucose monitoring. Patients using the vial must be prescribed the U-500 insulin syringe to avoid medication errors. Patients treated with insulin, including HUMULIN R U-500, and a PPAR-gamma agonist should be observed for signs and symptoms of heart failure. You may give other people a serious infection or get a serious infection from them. Take this Humulin R U - 500 Coupon to your nearest Food Lion Pharmacy to receive your discounted price. HUMULIN R U-500 is a concentrated insulin. Poorly controlled diabetes increases the fetal risk for major birth defects, stillbirth, and macrosomia-related morbidity. If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered. If it has been frozen, do not use it. Because it can be prescribed without other insulins, you may be able to reduce the number of insulins you take. Standard precautions as applied to use of HUMULIN R U-500 in adults are appropriate for use in children. More severe episodes with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose. DO NOT TRANSFER TO A SYRINGE Or call 1-800-LillyRx (1-800-545-5979). Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Please see accompanying Full Prescribing Information and Patient Information. For more information about Humulin R U-500 go to www.humulin.com. Copyright © 2015, 2019, Eli Lilly and Company. Humulin R U-500 has the empirical formula C 257 H 383 N 65 O 77 S 6 and a molecular weight of 5808.. Also tell your doctor about: For more information, call 1-800-545-5979 or go to humulin.com. You may give other people a serious infection or get a serious infection from them. Human insulin is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Prescribe patients a U-500 insulin syringe to administer HUMULIN R U-500 from the vial to avoid administration errors. How to recognize your HUMULIN R U-500 KwikPen. Humulin R U-500 (Concentrated) Coupons and Rebates Humulin R U-500 (Concentrated) offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. The HUMULIN R U-500 KwikPen dials in 5 unit increments. †Please see Instructions for Use included with your pen or click here. The HUMULIN R U-500 vial, which contains 20 mL, has a band of aqua coloring, a 500 units/mL concentration statement consisting of white lettering on a green rectangular background, and a green “U-500” statement prominently displayed next to the trade name. (BRAND) HUMULIN R U-500. Do not count clicks of the dose knob to select your dose. Humulin R (Concentrated) (U-500) Generic Name: insulin regular, concentrated (U-500) (IN soo lin) Brand Name: HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated) Medically reviewed by Drugs.com on April 6, 2020. Humulin®(HU-mu-lin)RU-500 insulin human injection (500units per mL) Do not share your HumulinR U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. If your dose is more than 300 units, you will need to give more than 1 injection. Humana Pharmacy’s received the highest score among mail order pharmacies in the J.D. All insulin products, including HUMULIN R U-500, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia. Inject your insulin as your healthcare provider has shown you. Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used. All rights reserved. Dosing errors have occurred when the HUMULIN R U-500 dose was administered with syringes other than a U-500 insulin syringe. Inspect Humulin R U-500 visually for particulate matter and discoloration. Do I have to convert my Humulin R U-500 insulin dose when I use the U-500 syringe? You can give from 5 to 250 units in one injection. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Ask your healthcare provider what your dose should be for your Pen in insulin units. Not In Use (Unopened) HUMULIN R U-500 KwikPen. The plunger will only reach the end of the cartridge when you have used all 1500 units in the Pen. Protect from heat and light. Do not reuse or share your needles with other people. Last updated on Nov 1, 2020. HUMULIN R U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than … Keep away from heat and out of direct light. Check your supply. Please read these instructions before use. Hood RC, Arakaki RF, Wysham C, et al. All rights reserved. Each line on the U-500 syringe measures 5 units of U-500 insulin. Pentamidine may cause hypoglycemia, which may sometimes be followed by hyperglycemia. When using the Humulin R U-500 vial: There is a special syringe to measure Humulin R U-500 called the "U-500 insulin syringe." It is more concentrated than standard insulin. A severe overdose can happen, causing very low blood sugar, which may put your life in danger. There are no well-controlled studies of use of HUMULIN R U-500 in children. Medically reviewed by Drugs.com. Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, and delivery complications. All rights reserved. Ask your healthcare provider what your dose should be for this Pen. You may not get enough insulin or you may get too much insulin. Regular insulin, also known as neutral insulin and soluble insulin is a type of short-acting insulin. HUMULIN R U-500 (500 units per mL) injection is available in a clear, colorless solution as: Medication errors associated with the HUMULIN R U-500 vial presentation resulting in patients experiencing hyperglycemia, hypoglycemia or death have been reported. Humulin R U‑500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day. What are the ingredients in Humulin R U-500? Fluid retention may lead to or exacerbate heart failure. Swelling of your hands and feet. SEND TEXT. Do not remove Humulin R U-500 from the KwikPen to inject with any syringe. The following adverse reactions are discussed elsewhere: The following additional adverse reactions have been identified during post-approval use of HUMULIN R U-500. The signs and symptoms of hypoglycemia [see Warnings and Precautions (5.4)] may be blunted when beta-blockers, clonidine, guanethidine, and reserpine are co-administered with HUMULIN R U-500. Any medical conditions, including problems with your liver, kidney, or heart. Always inject Humulin R U-500 insulin with a U-500 syringe. Your card is now activated and ready for use.