Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. The defined daily dose is 1 gram (by mouth) Side effects. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Currently, praziquantel is the only drug used for treatment of all five species of human schistosomes. Drug interactions with oxamniquine are not well known. 1. Back to top. Oxamniquine may be found in some form under the following brand names: This is not a complete list of Oxamniquinedrug interactions. We comply with the HONcode standard for trustworthy health information -. Oxamniquine is used only to treat infections caused by the worm Schistosoma mansoni. Version: 3.03. The FDA categorizes medications based on safety for use during pregnancy. What happens if I miss a dose? If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. Tell your doctor and pharmacist about all medicines you are taking, so that they can monitor your therapy for interactions. Oxamniquine is "an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Your pharmacist has more information about oxamniquine written for health professionals that you may read. de V Clarke V, Blair DM, Weber MC, Garnett PA. Treat to maintain ICP less than 20 mmHg and CPP between 40 and 50 mmHg. Clinical, laboratory and radiological examinations were performed before and after treatment. Five categories - A, B, C, D, and X, are used to classify the possible risks Dosage Oral, 15 mg per kg of body weight two times a day for one day. The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. It is generally well tolerated following oral doses. following (use any or all that apply): Oxamniquine is available in the following doses: Oxamniquine is available in the following forms: Enter multiple addresses on separate lines or separate them with commas. Praziquantel is a prescription drug used as anti-worm medication.It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.. Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water.Schistosoma worms are found in Africa, South America, Middle Eastern … Take oxamniquine with food to lessen stomach upset. Oxamniquine is usually taken in one or two doses that completely treat the infection. No studies have been done in animals, and no well-controlled studies have been done in No well-controlled studies have been done in humans, though. Store oxamniquine at room temperature away from moisture and heat. 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. Take oxamniquine exactly as prescribed by your doctor. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Take oxamniquine exactly as directed by your doctor. Dosage trial of a combination of oxamniquine and praziquantel in the treatment of schistosomiasis in Zimbabwean schoolchildren. It is also not known whether oxamniquine passes into breast milk and how it might affect a nursing baby. [54460] [54503] [54549] [64013] Severe traumatic brain injury guidelines recommend 2 to 5 mL/kg/dose IV over 10 to 20 minutes. CrCl . Select one or more newsletters to continue. born with problems. Coelho,2 C.M.F. If you experience dizziness, avoid these activities. Take each dose with a full glass of water. Available for Android and iOS devices. agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment. Continue to take oxamniquine and talk to your doctor if you experience. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. Rarely, seizures have occurred, most often in patients who already have epilepsy or another seizure disorder. Quinoline derivatives and related substances. Optimal dosage schedules vary for different regions of the world. Do not take oxamniquine without first talking to your doctor if you are breast-feeding a baby. 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. Oxamniquine is used for treatment of schistosomiasis. Dosage Oral, 15 mg per kg of body weight two times a day for one day. Antunes,3 C.A.P. Oxamniquine is a potent single-dose agent for treatment of S. mansoni infection in man, and it causes worms to shift from the mesenteric veins to the liver, where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … Therefore, this medication may be used if the potential benefits to the mother outweigh Chemotherapy protocols were (1) ALT, 60 mg/kg praziquantel (Pzq60); (2) AHT, one dose of 40 mg/kg Pzq followed by one dose of 20 mg/kg oxamniquine for one group and one dose of 40 mg/kg Pzq alone for the other group; (3) LIT, one dose of 40 mg/kg Pzq repeated every 3 months up to three doses. This medication may be prescribed for other uses. About 70% of a dose of oxamniquine is excreted as the 6-carboxy metabolite within 12 hours of a dose; traces of the 2-carboxy metabolite have also been detected in the urine. The use of any information on this site is solely at your own risk. The use of oral oxamniquine syrup or capsule in controlling endemic Schistosomia mansoni was studied in 191 residents of Castro Alves, northeast Brazil. Tell your doctor if you are pregnant or plan to become pregnant. The Oxamniquine dose your doctor recommends will be based on the Oxamniquine should be given to a pregnant woman only if clearly needed. Search for more papers by this author. Revision Date: 2/13/04 4:02:18 PM. Store oxamniquine at room temperature away from moisture and heat. Generic Name: oxamniquine (ox AM ni kwin)Brand Name: Vansil. [54460] [54503] [54549] [64013] Severe traumatic brain injury guidelines recommend 2 to 5 mL/kg/dose IV over 10 to 20 minutes. Use caution when driving, operating machinery, or performing other hazardous activities. Twenty patients (Group 1) were treated with a single oral dose of oxamniquine (15-20mg/kg body weight) and 15 (Group 2) were treated with cloramphenicol (50mg/kg body weight, for 15-20 days). The dosage of oxamniquine needed varies according to the geographic location where the infection was acquired (7). Because oxacillin may cause phlebitis, slow IV infusion is recommended; many infuse the drug over a 1 hour administration time. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide Ask your pharmacist any questions you have about this medication, especially if it is new to you. Ferrari,1 P.M.Z. There are no well-controlled studies that have been done in pregnant women. Ask your doctor or pharmacist for more information. Coelho,2 C.M.F. Dosage. Side Effects. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. Infants, Children, and Adolescents. In the western hemisphere and western Africa, the adult oxamniquine dosage is 12–15 mg/kg given once. Copyright 1996-2021 Cerner Multum, Inc. 250 mg capsules. Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoniinfection: a controlled trial M.L.A. Myelography may identify discrete granulomatous masses that may be amenable to surgical removal (8). Oxamniquine is not commercially available in the United States. Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021) and others. Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. pregnant women. VANSIL (Oxamniquine) David Schlossberg MD, FACP, FIDSA, FCPP. Oxamniquine is used for treatment of schistosomiasis. Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Actions. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Recommended dose In 2 Phase III NVAF clinical trials, approximately 95% of ELIQUIS® (apixaban) patients received this dose. to an unborn baby when a medication is taken during pregnancy. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … Steroids are used to suppress the host response around the ectopic eggs (5,6). Side effects other than those listed here may also occur. A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. Other, less serious side effects may be more likely to occur. 250 mg capsules. In geriatric patients, cautious dose selection is necessary because of decreased hepatic/renal/cardiac function and increased systemic exposure to cycloguanil; Dosing Modifications. abdominal pain, decreased appetite, or vomiting. Oxamniquine may also be used for purposes other than those listed in this medication guide. Other brand or generic formulations may also be available. Since only one or two doses are needed to treat this infection, you are not likely to miss a dose. It prevents worms from growing or multiplying in your body. Infuse appropriate dose at a rate to ensure that the entire dose is given before 10% or more of the drug is inactivated by the IV solution. Ask your doctor or pharmacist for more information. Find patient medical information for oxamniquine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ferrari,1 P.M.Z. Oxamniquine is used for treatment of schistosomiasis. Dosage Oxaminiquine's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage: 15 to 20 mg/kg: 18 (17.5) As recommended. This is an uncommon infection usually acquired through contact with freshwater in Africa. Since only one or two doses are needed to treat this infection, you are not likely to miss a dose. Do not take oxamniquine without first talking to your doctor if you are pregnant. Oxamniquine is con-traindicated in pregnancy. Seek emergency medical attention or call a poison control center near you. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. All information on this site is provided "as-is" for informational purposes only and is not a substitute for medical advice or treatment. Usual Adult Dose for Zollinger-Ellison Syndrome. Stop taking oxamniquine and seek emergency medical attention if you experience an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives). combinâtion of oxâmniquine (7.5 mg/kg) plus prâziquantel (20 mg/kg) against either. The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Oxamniquine is an "antihelmintic," or anti-worm, medication. Oxamniquine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. Abdominal pain (4-21%) Cough (14-25%) Depression (undefined) Diarrhea (19-42%) Dyspnea (15-21%) Fever (14-40%) Headache (16-31%) Infection (18-22%) Insomnia (10-19%) Myalgia (undefined) Nausea (21-32%) Rash (22-46%) Rhinitis (5-24%) Vomiting (14-22%) Weakness (8-31%) Ninety-one children with chronic schistosomiasis mansoni were selected for this double blind trial. Oxamniquine is available with a prescription under the brand name Vansil in 250 mg capsules. Oxamniquine is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Although oxamniquine and metrifonate have been used for schistosomiasis control, they are only effective against Schistosoma mansoni and S. haematobium, respectively. Oxamniquine is usually taken in one or two doses that completely treat the infection. 1986 Jul;32(7):165-7. In the western hemisphere and western Africa, the adult oxamniquine dosage is 12–15 mg/kg given once. Cent Afr J Med. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The efficacy of the antischistosomal drugs praziquantel and oxamniquine was tested on four groups of Ethiopian sugar estate workers. Availability. In South America, adults are given 15 mg/kg of body weight as a single oral dose; in children 20 mg/kg is preferred, given in two divided portions each of 10 mg/kg with an interval of 4–6 h between doses. The defined daily dose is 1 gram (by mouth) Side effects. Follow the directions on your prescription label carefully. Rafik Samuel MD, FACP, FIDSA, FCPP. Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoniinfection: a controlled trial M.L.A. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 48 (Group 1) were treated with a single oral dose of oxamniquine (20mg/kg body-weight) and 43 (Group 2) received the placebo. Antunes,3 C.A.P. It is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. The dose of oxamniquine varies with the geographical origin of the S. mansoni infection, the age and hence the surface area of the patient. Dose-finding trials of oral oxamniquine in Rhodesia. Oral: 40 mg orally 2 times a day-Maximum dose: 240 mg/day Parenteral:-Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes-Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes Before taking oxamniquine, tell your doctor about any other medical conditions that you have, especially liver disease, kidney disease, or a seizure disorder. Seek medical attention in the case of a seizure. the potential risks to the unborn child. You should consult with a medical professional if you have any questions about your health. oxamniquine oral ; Side Effects by Severity ; oxamniquine oral Generic Name(s): oxamniquine . Individuals weighing less than 25 kg were treated with 20 mg/kg of oxamniquine syrup and others were given 12.5-15 mg/kg as capsules. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Take oxamniquine with food to lessen stomach upset. It is generally well tolerated following oral doses. Actions. Availability. The Oxamniquine dose your doctor recommends will be based on the following (use any or all that apply): the condition being treated other medical conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender JTriclabendazole may be effective in a dosage of 5 mg/kg once/day X 3 days or 10 mg/kg bid X 1 day (Calvopina M, et al: Trans R Soc Trop Med Hyg 92:566, 1998). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This study sought to compare the effectiveness and side effects of praziquantel versus oxamniquine in treating 200 patients with Schistosoma mansoni infection and praziquantel versus metrifonate in treating 100 patients with S. haematobium infection. Dosage. In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. «Oxamniquine has been effective in some areas in which praziquantel is less effective (Stelma FF, et al: J Infect Dis 176:304, 1997). Oxamniquine may cause dizziness. Praziquantel and oxamniquine were given in single doses of 40 mg/kg body weight and 25 mg/kg, respectively. Optimal dosage schedules vary for different regions of the world. When split doses of these drugs were used, praziquantel achieved cure rates of 96, 95 and 89%, while the corresponding … You may need a lower dose or special monitoring if you have any of these conditions. In animal studies, pregnant animals were given this medication and had some babies Side Effects by Likelihood and Severity . The cure rates, determined by the absence of eggs in stools, were 96, 93 and 74% at one, three and six months post-treatment for patients receiving a single dose (40 mg kg-1 body weight) of praziquantel, and 82, 78 and 78% for patients on a single dose (15 mg kg-1 body weight) of oxamniquine. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%.
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